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Identification and mode of action studies of new potent inhibitors of the RNA viruses HCV, BVDV and RSV

Farci, Pamela (2012) Identification and mode of action studies of new potent inhibitors of the RNA viruses HCV, BVDV and RSV. [Doctoral Thesis]

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Abstract

Several of worldwide emerging infections are caused by RNA viruses. For this reason, research in the antiviral chemotherapy field is directed toward the development of compounds that target various steps of the virus life cycle. In this work the antiviral activity of 5-Acetyl-2- Arylbenzimidazoles and 2-[(benzotriazol-1/2 yl)methyl]benzimidazoles has been evaluated against representatives of several virus families, including HCV BVDV, YFV, REO-1, CVB-5, Sb-1 and RSV. Some of the new derivatives turned out to be very interesting for their potency and selectivity against BVDV and HCV (the former), and RSV (the latter), and could be promising candidates for the treatment of the related diseases.

Item Type:Doctoral Thesis
Date:29 March 2012
Tutor:La Colla, Paolo
PhD classes:Ciclo 24 > Sviluppo e sperimentazione dei farmaci antivirali
Coordinator:Pani, Alessandra
Institution:Universita' degli Studi di Cagliari
Divisions:Dipartimenti (fino a dicembre 2011) > Dipartimento di Scienze biomediche e biotecnologie
Subjects:Area 05 - Scienze biologiche > BIO/19 Microbiologia generale
Uncontrolled Keywords:HCV, BVDV, RSV, benzimidazoles, cytotoxicity, antiviral activity, virus epatite C, virus della diarrea bovina, benzimidazoli, citotossicità, attività antivirale
ID Code:761
Deposited On:30 Mar 2012 12:44

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