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-Novel indole-1-carbinols and 1,3'- Diindolylalkanes: synthesis and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells: preparation of tris-oxazoles building blocks for the total synthesis of telomestatin

Zedda, Gloria (2012) -Novel indole-1-carbinols and 1,3'- Diindolylalkanes: synthesis and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells: preparation of tris-oxazoles building blocks for the total synthesis of telomestatin. [Doctoral Thesis]

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Abstract

The first chapter of this thesis work describes an efficient and ecofriendly synthetic methodology of the known 1,3’-diindolylalkanes, which were recently brought to the forefront for their anti-carcinogenic properties. With a similar procedure, novel indole-1-carbinols and 1,3’-diindolylalkanes were synthesized and then subjected to preliminary cytotoxic evaluation on hepatocarcinoma cells, showing to be great potential anticancer drugs. The second chapter explores possible solutions to the unresolved issue presented by the oxidation of a dihydro precursor of the potent telomerase inhibitor, telomestatin. The assembly of key polyoxazole building blocks for that natural product is discussed.

Item Type:Doctoral Thesis
Date:15 March 2012
Tutor:Tocco, Graziella, Ciufolini, Marco A.
PhD classes:Ciclo 24 > Scienze e tecnologie farmaceutiche
Coordinator:Maccioni, Elias
Institution:Universita' degli Studi di Cagliari
Divisions:Dipartimenti (fino a dicembre 2011) > Dipartimento Farmaco chimico tecnologico
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Uncontrolled Keywords:Indole-N-carbinols, 1,3’-diindolylalkanes, telomestatin, tris-oxazoli
ID Code:701
Deposited On:20 Mar 2012 16:20

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