Melis, Miriam (2011) Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα. [Doctoral Thesis]
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SPECIFIC AIMS OF THE STUDY 1) To investigate whether FAEs can suppress nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of PPARα modulation on VTA DA neurons, and to examine the contribution of nAChRs in the effects. 3) To study whether PPARα modulation of nAChRs in VTA DA neurons might confer DA cells to access distinct firing patterns and/or to change their firing frequency both in vivo and in vitro. 4) To examine the physiological relevance of PPARα modulation of nAChR stimulation through behavioral analysis.
|Item Type:||Doctoral Thesis|
|Note:||In questa versione della tesi sono stati eliminati articoli tutelati dalla normativa sul copyright|
|Date:||27 January 2011|
|PhD classes:||Ciclo 23 > Neuroscienze|
|Institution:||Universita' degli Studi di Cagliari|
|Divisions:||Dipartimenti (fino a dicembre 2011) > Dipartimento di Neuroscienze|
|Subjects:||Area 05 - Scienze biologiche > BIO/14 Farmacologia|
|Uncontrolled Keywords:||dopamine, acetylcholine, electrophysiology, neuron, peroxisome, proliferator-activated receptor, ventral tegmental area|
|Deposited On:||17 May 2011 13:20|
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- Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα. (deposited 17 May 2011 13:13)
- Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα. (deposited 17 May 2011 13:20) [Currently Displayed]
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