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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα

Melis, Miriam (2011) Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα. [Doctoral Thesis]

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Abstract

SPECIFIC AIMS OF THE STUDY 1) To investigate whether FAEs can suppress nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of PPARα modulation on VTA DA neurons, and to examine the contribution of nAChRs in the effects. 3) To study whether PPARα modulation of nAChRs in VTA DA neurons might confer DA cells to access distinct firing patterns and/or to change their firing frequency both in vivo and in vitro. 4) To examine the physiological relevance of PPARα modulation of nAChR stimulation through behavioral analysis.

Item Type:Doctoral Thesis
Note:In questa versione della tesi sono stati eliminati articoli tutelati dalla normativa sul copyright
Date:27 January 2011
Tutor:Pistis, Marco
PhD classes:Ciclo 23 > Neuroscienze
Coordinator:Concas, Alessandra
Institution:Universita' degli Studi di Cagliari
Divisions:Dipartimenti (fino a dicembre 2011) > Dipartimento di Neuroscienze
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Uncontrolled Keywords:dopamine, acetylcholine, electrophysiology, neuron, peroxisome, proliferator-activated receptor, ventral tegmental area
ID Code:658
Deposited On:17 May 2011 13:20

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