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Indagine etnofarmacologica su Casimiroa edulis Llave et Lex

Sanna, Cinzia (2008) Indagine etnofarmacologica su Casimiroa edulis Llave et Lex. [Doctoral Thesis]



In order to evaluate the effects produced by the extracts of leaves, seeds and bark from Casimiroa edulis cultivated in Sardinia on the central nervous system, different behavioral tests were performed: spontaneous motor activity, anxyolitic, antidepressant, hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced paw edema it showed an antinflammatory activity; furthermore it reduced writhing acetic acid-induced (antinociceptive activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced catalepsy haloperidol and PTZ-induced. The extract of bark significantly reduced immobility time in the FST and it increased pentobarbital-induced hypnosis.

Item Type:Doctoral Thesis
Date:18 December 2008
Tutor:Ballero, Mauro
PhD classes:Ciclo 21 > Farmacologia delle tossicodipendenze
Coordinator:Di Chiara, Gaetano
Institution:Universita' degli Studi di Cagliari
Divisions:Dipartimenti (fino a dicembre 2011) > Dipartimento di Scienze botaniche
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Uncontrolled Keywords:Casimiroa edulis, antidepressant, sedative, anxyolitic, anticonvulsant
ID Code:449
Deposited On:04 Dec 2009 13:28

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