Banni, Stefano - Angioni, E. - Carta, G. - Dessi, M. Assunta - Melis, M. Paola - Murru, E. - Scanu, P. - Spada, Sebastiano - Vargiolu, Silvana - Corongiu, Francesco P. (2000) Modificazioni dei livelli di acido arachidonico e vitamina A in relazione alla attività anticancerogena attribuita all'apporto alimentare di burro naturalmente arricchito in acido linoleico a dieni coniugati (CLA). Rendiconti del Seminario della Facoltà di Scienze dell'Università di Cagliari, 70 (Supple). pp. 28-34. ISSN 0370727X
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Considerable attention has recently been directed to the naturally occurring trace fatty acid conjugated linoleic acid (CLA), based on its dual ability to act both as a preventive and therapeutic agent in a number of rodent and human tumor model systems. CLA, which is synthesized by rumen bacteria, is found in meat and dairy products, and is of particular interest since it is effective at low levels in the diet. Our research interest is to explore whether the mechanism of the anticarcinogenic activity of CLA may be reconductible to its metabolism and influence on tissue lipid metabolism. CLA is a polyunsaturated fatty acid (PUFA) with two singular properties: 1) Its metabolism is alike that of linoleic acid and thus competes with the latter for the elongation and desaturation enzyme systems, leading on one hand to a decreased generation of eicosatrienoic and arachidonic acids for eicosanoid synthesis, and on the other to a replacement of the natural substrates with CLA metabolites known to inhibit the cyclooxigenase (COX) and lipooxygenase (LPOX) pathways; and 2) It increases the retinol content of different tissues, an effect that may be due to β-oxidation of CLA by peroxisomes with consequent activation of peroxisome proliferator activated receptor a (PPARα). The effects of CLA on eicosanoid synthesis may be the key factor of a common mechanism underlying its pleiotropic activities, and our current working hypothesis is that this factor along with tissue retinol increase, mediate the anticarcinogenic action of CLA.
|Institution:||Università degli Studi di Cagliari|
|Divisions:||Centri > Seminario Scientifico della Facolta' di Scienze MM.FF.NN.|
|Subjects:||Area 05 - Scienze biologiche > BIO/10 Biochimica|
|Uncontrolled Keywords:||Acido linoleico a dieni coniugati, metabolismo degli acidi grassi polinsaturi, retinolo, cancerogenesi mammaria.|
|Deposited On:||12 Nov 2008 10:40|
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