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Attività dello squalene durante l'autossidazione di acidi grassi poliinsaturi

Dessi, M. Assunta - Deiana, Monica - Arras, Cristina - Rosa, Antonella - Banni, Stefano - Corongiu, Francesco P. (2000) Attività dello squalene durante l'autossidazione di acidi grassi poliinsaturi. Rendiconti del Seminario della Facoltà di Scienze dell'Università di Cagliari, 70 (Supple). pp. 2-13. ISSN 0370727X

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Abstract

In this paper we have investigated the activity of squalene during the autoxidation of four different polyunsaturated fatty acids: linoleic, linolenic, arachidonic and docosahexaenoic acids. Our results show that squalene exerts a weak but significant antioxidant activity, and that squalene hydroperoxide, the product derived from squalene oxidation, does not possess prooxidant activity. The protection exerted by squalene is higher versus linolenic, arachidonic and docosahexaenoic acids than linoleic acid. Squalene antioxidant activity is related to its double bond system since its saturated form, squalane, does not exert any inhibitory activity. Therefore, in our experimental conditions, squalene does not act as a hydrogen atoms donor such as α-tocopherol.

Item Type:Article
Date:2000
Institution:Università degli Studi di Cagliari
Divisions:Centri > Seminario Scientifico della Facolta' di Scienze MM.FF.NN.
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Uncontrolled Keywords:Squalene, PUFA, autossidazione, idroperossido, antiossidante
ID Code:287
Deposited On:12 Nov 2008 08:56

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