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Studies on the role of cholesterol in the pathogenesis of prion diseases: I. Correlation between cell susceptibility to prion infection/replication and altered cellular cholesterol distribution

Cannas, Maria Dolores (2007) Studies on the role of cholesterol in the pathogenesis of prion diseases: I. Correlation between cell susceptibility to prion infection/replication and altered cellular cholesterol distribution. [Doctoral Thesis]

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Abstract

The aim of the research project was to investigate whether cell susceptibility to prion infection/replication was somehow related to alterations in the intracellular cholesterol homeostasis, and in particular whether unbalanced FC vs. CE pools could be found in prion infected/prion susceptible cells with respect to cell conditions of no infection or genetic resistance.

Item Type:Doctoral Thesis
Date:27 November 2007
Tutor:Pani, Alessandra
PhD classes:Ciclo 20 > Sviluppo e sperimentazione dei farmaci antivirali
Coordinator:La Colla, Paolo
Institution:Universita' degli Studi di Cagliari
Divisions:Dipartimenti (fino a dicembre 2011) > Dipartimento di Scienze e tecnologie biomediche
Subjects:Area 05 - Scienze biologiche > BIO/19 Microbiologia generale
Uncontrolled Keywords:prion infection, cholesterol
ID Code:127
Deposited On:04 Nov 2008 09:12

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